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IGF One Pathways

Meaning

IGF One Pathways describe the complex intracellular and systemic signaling cascades initiated by Insulin-like Growth Factor-1 (IGF-1), a peptide hormone primarily synthesized in the liver in response to Growth Hormone (GH) stimulation. These pathways are crucial mediators of GH’s anabolic effects, promoting cell proliferation, differentiation, and survival in numerous tissues, including muscle, bone, and cartilage. The principal mechanism involves IGF-1 binding to its receptor, which subsequently activates the PI3K/Akt and MAPK signaling routes. Modulating these pathways is central to therapeutic strategies aimed at tissue repair, metabolic health, and functional longevity.