What is the Origin of IGF One Axis?

This term originates from the study of growth factors and endocrinology, specifically defining the relationship between Growth Hormone and its primary effector molecule, IGF-1. The system is also known as the GH-IGF-1 axis.

What is the Mechanism of IGF One Axis?

Growth Hormone is released by the anterior pituitary and stimulates the liver to produce IGF-1. Circulating IGF-1 then acts on target cells by binding to the IGF-1 receptor, triggering intracellular signaling cascades that promote protein synthesis and inhibit apoptosis. The activity of this axis is tightly regulated by negative feedback, where IGF-1 can inhibit GH release, ensuring precise control over growth and metabolism.

IGF One Axis

Meaning

The Insulin-like Growth Factor-1 (IGF-1) axis is a critical endocrine pathway primarily regulated by Growth Hormone (GH), linking the pituitary gland, the liver, and peripheral tissues. IGF-1 is a potent anabolic peptide hormone essential for cell proliferation, tissue growth, and repair, mediating many of the effects of GH throughout the body. Clinically, this axis is a key indicator of growth status, metabolic health, and biological aging.