What is the Origin of IGF-I Levels?

IGF-I's discovery is rooted in endocrinology, following research into the growth-promoting effects of pituitary extracts, which were later found to be mediated by this peripheral factor. Its existence reflects the endocrine cascade downstream of GH release.

What is the Mechanism of IGF-I Levels?

IGF-I mediates most of the anabolic and growth-promoting effects of GH by binding to its own receptor, activating the PI3K/Akt pathway, which promotes cell proliferation and protein synthesis. Monitoring these levels helps clinicians assess the efficacy of GH administration or diagnose growth hormone deficiency or excess conditions.

IGF-I Levels ∞ Area

IGF-I Levels

Meaning

Measurement of circulating levels of Insulin-like Growth Factor-I, a key polypeptide hormone primarily synthesized in the liver under the direct stimulation of Growth Hormone (GH). It is a vital biomarker for assessing the somatotropic axis function and nutritional status.