What is the Origin of IGF-I Cascade Support?

The concept originates from the study of the somatotropic axis, where IGF-I was identified as the primary mediator of GH's growth-promoting effects throughout the body. The term 'cascade' highlights the sequential nature of the signaling, beginning with hypothalamic GHRH and culminating in IGF-I's systemic action. Supporting this cascade is a modern therapeutic target for age-related frailty.

What is the Mechanism of IGF-I Cascade Support?

Support involves ensuring adequate upstream GH signaling, often through GHRH analogs, alongside sufficient nutritional status for hepatic protein synthesis. Once released, IGF-I binds to its receptor, initiating a complex intracellular signaling cascade, notably through the PI3K/Akt pathway. This pathway promotes cellular survival, inhibits apoptosis, and stimulates protein synthesis in target tissues like muscle and bone, thereby driving systemic anabolism.

IGF-I Cascade Support ∞ Area

IGF-I Cascade Support

Meaning

IGF-I Cascade Support is a clinical strategy aimed at promoting the healthy and robust signaling pathway mediated by Insulin-like Growth Factor-I (IGF-I), a potent anabolic peptide primarily produced by the liver in response to Growth Hormone (GH). This support is essential for maintaining muscle mass, bone density, and overall tissue integrity. It is a critical component of anti-aging and regenerative medicine, particularly in mitigating the effects of somatopause.