IGF-I Axis Support refers to clinical and lifestyle strategies aimed at optimizing the function of the Insulin-like Growth Factor I (IGF-I) axis, a critical pathway downstream of Growth Hormone (GH) that mediates anabolic effects throughout the body. IGF-I, primarily produced by the liver in response to GH, is essential for cellular growth, tissue repair, and maintaining lean body mass and bone density. Supporting this axis involves ensuring adequate nutritional intake, optimizing sleep quality, and incorporating resistance exercise to promote healthy GH secretion and hepatic IGF-I synthesis.
Origin
This concept originates from the field of endocrinology, following the discovery that many of Growth Hormone’s effects are indirect, mediated by the potent polypeptide IGF-I. The “axis” terminology reflects the hypothalamic-pituitary-liver signaling cascade that regulates IGF-I production. The clinical focus on “support” emerged from recognizing that IGF-I levels naturally decline with age (somatopause) and are highly sensitive to nutritional status, making it a key target for longevity and anti-aging interventions.
Mechanism
The support mechanism begins with the hypothalamus releasing Growth Hormone-Releasing Hormone (GHRH), stimulating the pituitary to secrete GH. GH then acts on target organs, predominantly the liver, which subsequently synthesizes and releases IGF-I into the circulation. IGF-I acts locally and systemically to promote protein synthesis and cell proliferation by binding to its cognate receptor. Adequate protein intake and regular, high-intensity exercise are powerful modulators that enhance GHRH and GH pulsatility, thereby naturally supporting the entire axis and its anabolic output.
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