What is the Meaning of IGF-I?

IGF-I, or Insulin-like Growth Factor-I, is a potent anabolic peptide hormone structurally homologous to insulin, playing a critical role in growth, cellular proliferation, and tissue repair. Primarily synthesized in the liver in response to growth hormone (GH) stimulation, IGF-I mediates many of the growth-promoting effects of GH throughout the lifespan. Circulating levels are used clinically as a reliable marker of average growth hormone secretion. Its functions extend beyond growth, significantly influencing metabolism, bone density, and muscle maintenance.

What is the Origin of IGF-I?

The name "Insulin-like Growth Factor" was assigned because the peptide exhibited growth-promoting effects and showed structural similarity to the pro-insulin molecule. The Roman numeral "I" distinguishes it from its counterpart, IGF-II. Its role as the primary mediator of growth hormone action was elucidated in the latter half of the 20th century, establishing the GH-IGF-I axis as central to somatic growth.

What is the Mechanism of IGF-I?

Growth Hormone (GH) released from the pituitary gland travels to the liver, where it binds to GH receptors, initiating a signaling cascade that stimulates the synthesis and secretion of IGF-I. Circulating IGF-I then acts in an endocrine, paracrine, and autocrine manner by binding to the IGF-I receptor (IGF-1R) on target cells in tissues such as muscle, bone, and cartilage. This binding activates the receptor's intrinsic tyrosine kinase activity, initiating downstream pathways like the PI3K/Akt pathway, which promotes cell survival, protein synthesis, and tissue growth.

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IGF-I

Meaning

Origin

Mechanism

What Specific Hormonal Markers Are Typically Included in Standard Wellness Screenings?

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What Specific Biological Markers Are Assessed in Wellness Screenings?

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Are There Lifestyle or Nutritional Strategies That Can Support Heart Health during Growth Hormone Therapy?

What Specific Biomarkers Should Be Monitored during Peptide-Based Growth Hormone Protocols?

Can Moderate Alcohol Consumption Impact Peptide Therapy Outcomes?

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