Question 1

What is the Meaning of IGF-1R?

Accepted Answer

IGF-1R, or the Insulin-like Growth Factor-1 Receptor, is a transmembrane tyrosine kinase receptor protein found ubiquitously on the surface of most human cells. This receptor serves as the primary mediator of the biological effects of Insulin-like Growth Factor-1 (IGF-1) and, to a lesser extent, IGF-2. It is a crucial component of the growth and metabolic signaling network, regulating cell survival, proliferation, and tissue growth throughout the lifespan. Dysfunction or overactivation of the IGF-1R signaling pathway is implicated in both growth disorders and the pathogenesis of several malignancies.

Question 2

What is the Origin of IGF-1R?

Accepted Answer

The receptor's discovery is rooted in the early investigation of growth-promoting serum activity, which was initially termed "sulfation factor" and later identified as the action of IGF-1. The receptor itself was structurally characterized as a close homolog of the insulin receptor, leading to its nomenclature. IGF-1R is encoded by the IGF1R gene, located on human chromosome 15, signifying its fundamental role in mammalian development and physiology. Its origin as a molecular entity highlights the evolutionary link between growth regulation and nutrient sensing pathways.

Question 3

What is the Mechanism of IGF-1R?

Accepted Answer

The mechanism of IGF-1R activation is initiated by the binding of its ligand, IGF-1, to the receptor's extracellular alpha subunits. This binding event induces a conformational change that activates the intrinsic tyrosine kinase domain located on the intracellular beta subunits. The activated kinase then catalyzes the autophosphorylation of specific tyrosine residues, which serve as docking sites for various intracellular signaling proteins. This ultimately triggers a complex cascade, predominantly activating the PI3K/AKT and RAS/MAPK pathways, resulting in downstream effects such as increased protein synthesis, anti-apoptosis signaling, and enhanced cell division.

IGF-1R

Meaning

Origin

Mechanism

What Are the Long-Term Safety Considerations for Peptide Therapies and Prostate Health?

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours