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IGF-1 Signaling Pathways

Meaning

These pathways describe the complex intracellular routes activated upon the binding of IGF-1 to its cognate receptor, the IGF-1R, a transmembrane receptor tyrosine kinase. Activation triggers a cascade that profoundly influences cellular survival, proliferation, and metabolism, acting downstream of the somatotropic axis. Understanding these specific routes allows clinicians to predict tissue-level responses to changes in systemic IGF-1 concentrations.