What is the Origin of IGF-1 Signaling Cascade?

IGF-1 is the abbreviation for Insulin-like Growth Factor 1. Signaling Cascade is a biological term emphasizing the relay of information from the cell surface receptor down to the nucleus, involving a series of activation steps.

What is the Mechanism of IGF-1 Signaling Cascade?

Upon IGF-1 binding, the intrinsic tyrosine kinase activity of the IGF-1 receptor is activated, leading to the phosphorylation of intracellular substrate proteins, such as IRS-1. This phosphorylation event recruits adaptor molecules, initiating two major downstream pathways: the PI3K/Akt pathway, which promotes cell survival and protein synthesis, and the MAPK pathway, which drives cellular proliferation and differentiation.

IGF-1 Signaling Cascade

Meaning

The sequential chain of molecular events initiated by the binding of Insulin-like Growth Factor 1 (IGF-1) to its specific receptor, leading to a complex array of intracellular responses that govern cellular proliferation, differentiation, and survival. This cascade is a primary mediator of growth hormone’s anabolic effects.