This discipline focuses on the scientific principles governing the enhancement of Insulin-like Growth Factor 1 (IGF-1) activity to promote tissue anabolism, cellular repair, and metabolic health, while carefully managing associated risks. Optimization requires understanding the interplay between growth hormone secretion and nutritional status. It is the application of endocrinology to maximize regenerative potential.
Origin
IGF-1 is a polypeptide hormone produced primarily by the liver in response to Growth Hormone stimulation. ‘Optimization science’ frames the clinical pursuit of leveraging this powerful anabolic mediator through evidence-based protocols. The focus is on maximizing the beneficial effects of the somatotropic axis.
Mechanism
Optimization strategies typically involve maximizing pulsatile Growth Hormone release through interventions like intermittent fasting or specific amino acid profiles, which directly drives hepatic IGF-1 production. Furthermore, ensuring adequate insulin sensitivity and nutrient partitioning supports the downstream signaling of IGF-1 through its receptor, enhancing protein synthesis in peripheral tissues. This coordinated effort supports systemic growth factor action.
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