What is the Origin of IGF-1 Mediated Anabolism?

The term is rooted in endocrinology and metabolic physiology, recognizing IGF-1 as the primary effector of Growth Hormone's anabolic actions. The phrase emphasizes the direct role of this growth factor in promoting the constructive phase of metabolism.

What is the Mechanism of IGF-1 Mediated Anabolism?

IGF-1 binds to the IGF-1 receptor on target cell membranes, initiating a complex intracellular signaling cascade, notably the PI3K/Akt/mTOR pathway. Activation of this pathway directly stimulates the machinery responsible for protein translation and inhibits pathways that promote protein degradation, resulting in a net positive balance of tissue accretion and repair.

IGF-1 Mediated Anabolism

Meaning

IGF-1 Mediated Anabolism is the physiological process of tissue building and repair driven specifically by Insulin-like Growth Factor 1 (IGF-1), a peptide hormone predominantly synthesized in the liver in response to Growth Hormone (GH). This mechanism is critical for stimulating cellular uptake of amino acids and glucose, promoting protein synthesis, and facilitating the growth and maintenance of skeletal muscle and bone tissue. It is a powerful marker and driver of systemic regenerative capacity.