What is the Origin of IGF-1 Levels?

The term "IGF-1" is an acronym for Insulin-like Growth Factor 1, so named because of its structural homology to proinsulin and its ability to stimulate cell growth. The concept of a GH-dependent "sulfation factor" that mediated GH's effects was proposed in the 1950s, but the factor itself was later isolated and renamed IGF-1 in the 1970s. The measurement of its circulating "levels" became a standard endocrinological tool for diagnosing growth disorders and somatopause.

What is the Mechanism of IGF-1 Levels?

The primary mechanism by which IGF-1 operates is through binding to the Insulin-like Growth Factor 1 Receptor (IGF-1R), a tyrosine kinase receptor found on the surface of most cells. This binding initiates a complex intracellular signaling cascade, notably the PI3K/Akt pathway, which promotes cell survival, protein synthesis, and tissue accretion. Since GH is secreted in a pulsatile manner, the liver's continuous release of IGF-1 provides a stable, long-lasting signal that sustains anabolic processes throughout the body.

IGF-1 Levels

Meaning

IGF-1 Levels refer to the measured concentration of Insulin-like Growth Factor 1 in the peripheral circulation, a potent anabolic peptide hormone primarily synthesized in the liver in response to growth hormone (GH) stimulation. IGF-1 acts as the major mediator of many of GH’s effects, influencing cell proliferation, tissue growth, and metabolic regulation. Clinically, measuring serum IGF-1 provides a stable, integrated assessment of the functional status of the entire Growth Hormone-IGF-1 axis.

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