IGF-1 Level Restoration is a clinical objective focused on raising the circulating concentration of Insulin-like Growth Factor 1 to an optimal, physiologically appropriate range, often targeting levels associated with youthful health. IGF-1 is a key anabolic peptide hormone primarily produced by the liver in response to Growth Hormone (GH) stimulation. Restoring its levels is vital for supporting lean body mass, bone density, and cognitive function, especially in cases of somatopause or GH deficiency. This is a crucial strategy for maintaining anabolic drive in the aging body.
Origin
The concept is rooted in the discovery of the somatotropic axis, the complex regulatory loop involving the hypothalamus, pituitary, and liver, which controls growth and metabolism. IGF-1 was identified as the primary endocrine mediator of Growth Hormone’s anabolic effects, leading to its use as a measurable biomarker for GH status. The term ‘restoration’ reflects the clinical practice of correcting age-related or pathological decline in this crucial factor to improve systemic anabolism.
Mechanism
Restoration is typically achieved through the administration of exogenous Growth Hormone or Growth Hormone Releasing Hormones (GHRHs), which stimulate the liver to synthesize and secrete IGF-1. Once released, IGF-1 circulates and binds to the IGF-1 receptor on target cells throughout the body, activating the PI3K/Akt signaling pathway. This cascade promotes protein synthesis, cellular proliferation, and inhibits apoptosis, thereby driving tissue repair, muscle growth, and overall anabolic state.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.