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IGF-1 Level Normalization

Meaning

IGF-1 Level Normalization is the clinical objective of adjusting circulating Insulin-like Growth Factor 1 concentrations to fall within a range statistically associated with peak health, metabolic function, and tissue integrity, typically mirroring youthful averages. IGF-1, primarily produced by the liver in response to Growth Hormone, acts as a critical mediator of anabolic processes, cellular repair, and neuroprotection. This normalization is a key component of somatopause intervention strategies, aiming to restore the systemic anabolic drive that diminishes with age. Achieving the appropriate level is crucial, as both deficiency and excessive elevation carry distinct clinical risks.