The clinical oversight and modulation of circulating Insulin-like Growth Factor 1 (IGF-1) concentrations to ensure they align with optimal anabolic and metabolic requirements for the individual’s age and physiology. IGF-1 serves as the primary mediator of Growth Hormone’s peripheral anabolic actions. Management is essential for supporting tissue maintenance, lean mass accretion, and metabolic health.
Origin
This practice originates from the study of the somatotropic axis, where IGF-1 measurement became a standard proxy for assessing integrated GH action over time. Management is necessary because IGF-1 levels are sensitive to nutritional status, liver function, and insulin sensitivity.
Mechanism
IGF-1 levels are predominantly synthesized by the liver in response to Growth Hormone stimulation, though local production occurs in other tissues. Management techniques focus on optimizing GH pulsatility and ensuring adequate hepatic insulin signaling, as insulin is permissive for GH action on the liver. Reducing chronic inflammation also supports the sensitivity of IGF-1 receptors on target cells.
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