What is the Origin of IGF-1 Level Maintenance?

IGF-1 was first identified for its insulin-like properties, with its full role as the primary endocrine mediator of GH action elucidated in the mid-20th century. The term 'maintenance' emphasizes the clinical goal of sustained equilibrium rather than transient elevation, reflecting a sophisticated understanding of the pulsatile GH-IGF-1 axis.

What is the Mechanism of IGF-1 Level Maintenance?

The liver is the primary site of IGF-1 synthesis, which is directly stimulated by pituitary-released Growth Hormone. Maintenance strategies involve optimizing lifestyle factors, such as nutrition and sleep, to enhance endogenous GH pulsatility, or, in cases of deficiency, administering exogenous GH or IGF-1 analogs to ensure adequate systemic signaling for tissue growth and repair via the IGF-1 receptor pathway.

IGF-1 Level Maintenance

Meaning

The clinical process of monitoring and sustaining the circulating concentration of Insulin-like Growth Factor 1 (IGF-1) within a healthy, age-appropriate reference range to support systemic anabolism and cellular repair. IGF-1 is a crucial mediator of Growth Hormone (GH) action, and its proper maintenance is essential for bone density, muscle mass preservation, and neurological function. Precise regulation is key to maximizing its benefits while mitigating potential risks.