What is the Origin of IGF-1 Generation Test?

This clinical term is descriptive, referring to a test designed to measure the capacity for generation of the key downstream effector hormone, IGF-1. It was developed as a necessary diagnostic complement to simple Growth Hormone and IGF-1 level measurements. The test helps distinguish between a primary Growth Hormone deficiency and a secondary issue of tissue unresponsiveness.

What is the Mechanism of IGF-1 Generation Test?

The test involves collecting baseline IGF-1 levels, administering a specified dose of Growth Hormone, and then monitoring the subsequent rise in IGF-1 concentration over a set period. A significant, robust increase indicates normal tissue sensitivity. Conversely, a blunted or absent rise suggests that the Growth Hormone receptors are non-functional or the liver's capacity to synthesize IGF-1 is impaired, impacting systemic anabolic and regenerative functions.

IGF-1 Generation Test ∞ Area

IGF-1 Generation Test

Meaning

The IGF-1 Generation Test is a specialized dynamic endocrine function test used to evaluate the responsiveness of the liver and peripheral tissues to Growth Hormone stimulation. This diagnostic procedure assesses the entire pituitary-liver axis by measuring the resultant increase in circulating Insulin-like Growth Factor 1 levels after a standardized administration of exogenous Growth Hormone. It is a key tool for diagnosing conditions of Growth Hormone insensitivity.