Question 1

What is the Meaning of IGF-1 Generation?

Accepted Answer

IGF-1 Generation refers to the biological process of synthesizing and releasing Insulin-like Growth Factor-1, a crucial anabolic peptide, primarily by the liver in direct response to circulating Growth Hormone (GH) stimulation. This process is a central component of the somatotropic axis, mediating most of the growth-promoting, metabolic, and tissue-repair effects of GH on peripheral target tissues. The circulating concentration of IGF-1 serves as a stable, integrated biomarker reflecting the overall secretory status and action of Growth Hormone over a period of time.

Question 2

What is the Origin of IGF-1 Generation?

Accepted Answer

The concept originated from the discovery that the effects of GH were largely indirect, mediated by a circulating factor initially termed "sulfation factor," which was later definitively identified as IGF-1. The term "generation" highlights the liver's role as the primary endocrine source for this vital growth mediator, which is itself a peptide hormone. This GH-IGF-1 axis is a fundamental cascade in endocrinology, governing somatic growth during childhood and tissue maintenance in adulthood.

Question 3

What is the Mechanism of IGF-1 Generation?

Accepted Answer

The primary mechanism is the transcriptional activation of the IGF-1 gene within hepatocytes, which is initiated when Growth Hormone binds to its specific receptors on the liver cell surface. This receptor binding activates the intracellular JAK/STAT signaling pathway, leading to increased synthesis and subsequent secretion of the IGF-1 peptide into the bloodstream. Once secreted, IGF-1 circulates predominantly bound to various binding proteins, which modulate its half-life and local delivery to target tissues such as bone, muscle, and cartilage, where it promotes cell proliferation and differentiation.

IGF-1 Generation

Meaning

Origin

Mechanism

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