What is the Origin of IGF-1 Function?

The hormone was originally isolated and named based on its insulin-like metabolic effects and its role as a growth factor, distinct from but regulated by pituitary growth hormone. The concept of IGF-1 acting as the primary effector of GH, rather than GH acting directly on all target tissues, is known as the Somatomedin Hypothesis. This endocrine relationship is a fundamental principle of the somatotropic axis.

What is the Mechanism of IGF-1 Function?

IGF-1 exerts its function by binding to the IGF-1 receptor, a tyrosine kinase receptor found on the surface of most cells, initiating intracellular signaling cascades. These pathways promote protein synthesis, inhibit apoptosis, and regulate glucose metabolism, often acting as a potent anabolic agent. Circulating IGF-1 levels are closely monitored in clinical practice as an indicator of overall growth hormone status and nutritional sufficiency.

IGF-1 Function ∞ Area

IGF-1 Function

Meaning

The physiological role of Insulin-like Growth Factor 1, a polypeptide hormone primarily synthesized in the liver in response to growth hormone (GH) stimulation. IGF-1 is a key mediator of growth hormone’s anabolic effects, promoting cellular proliferation, differentiation, and survival across numerous tissues. Its function is central to skeletal and muscle growth, as well as the maintenance of tissue integrity throughout adulthood.