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IGF-1 Dysregulation

Meaning

IGF-1 dysregulation refers to an abnormal, non-homeostatic concentration or action of Insulin-like Growth Factor-1, a key anabolic hormone whose levels are largely mediated by Growth Hormone (GH) signaling in the liver. Dysregulation can manifest as either a deficiency, often associated with growth impairment and metabolic decline, or an excess, which is clinically linked to conditions like acromegaly and potentially increased cellular proliferation. Because IGF-1 is a potent mediator of cell growth, survival, and metabolism, its precise control is fundamental to optimal hormonal balance and the management of biological aging. Clinical assessment of IGF-1 levels helps guide Growth Hormone therapy decisions.