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IGF-1 Decline

Meaning

Insulin-like Growth Factor 1 (IGF-1) decline refers to the age-associated reduction in circulating levels of this anabolic peptide hormone, which mediates much of the growth hormone (GH) axis’s peripheral effects. This decrease signifies a functional shift in the somatotropic system, impacting tissue maintenance and metabolic homeostasis. Low IGF-1 levels are frequently correlated with sarcopenia, reduced bone mineral density, and impaired cellular repair mechanisms in older adults. Assessing this parameter offers insight into an individual’s overall anabolic capacity.