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IGF-1 Concentration Monitoring

Meaning

IGF-1 Concentration Monitoring is the clinical practice of regularly measuring the circulating levels of Insulin-like Growth Factor 1 (IGF-1), a key polypeptide hormone primarily produced by the liver in response to growth hormone (GH) stimulation. As IGF-1 levels are far more stable and longer-lived than the pulsatile GH, its concentration serves as a reliable, integrated surrogate marker for the overall biological activity of the GH axis. This monitoring is essential for diagnosing growth disorders, assessing the efficacy and safety of growth hormone replacement therapy, and evaluating potential risks associated with excessive GH signaling in longevity protocols.