What is the Origin of IGF-1 Brain Function?

The study of IGF-1's role in the brain evolved from endocrinology and developmental biology, initially focusing on its systemic growth-promoting effects. Later research demonstrated its capacity to cross the blood-brain barrier and its local synthesis within the brain, establishing it as a key neuroendocrine regulator. Its clinical significance relates to conditions where cognitive decline correlates with reduced circulating IGF-1 levels.

What is the Mechanism of IGF-1 Brain Function?

IGF-1 exerts its influence by binding to the IGF-1 receptor, activating intracellular pathways such as the PI3K/Akt and MAPK cascades, which are vital for cell proliferation and anti-apoptotic signaling. It modulates neurotransmitter release and enhances synaptic plasticity, which is the basis for learning and memory. Furthermore, IGF-1 supports cerebral vascular health, ensuring adequate nutrient and oxygen supply to the neural tissue.

IGF-1 Brain Function

Meaning

The multifaceted role of Insulin-like Growth Factor 1 (IGF-1) in promoting neurogenesis, synaptogenesis, and neuronal survival within the central nervous system. This peptide hormone acts as a crucial link between systemic metabolic status and brain health, mediating many of the neurotrophic effects of Growth Hormone. Optimal IGF-1 signaling is essential for cognitive function, mood regulation, and protecting against neurodegeneration.