A therapeutic strategy focused on modulating the systemic concentration and bioavailability of Insulin-like Growth Factor 1 (IGF-1) to achieve specific clinical endpoints, particularly those related to anabolism, tissue repair, and cellular maintenance. IGF-1 serves as a critical proxy and effector of growth hormone action.
Origin
The phrase uses the established biochemical abbreviation ‘IGF-1’, the clinical term ‘Biomarker’ (a measurable indicator), and ‘Targeting’ (the act of directing an intervention). It defines a focus within the growth axis.
Mechanism
Targeting involves interventions, often nutritional or peptidic, designed to influence the hepatic production and peripheral tissue response to IGF-1. The goal is not simply to raise the level but to ensure appropriate pulsatile release and tissue sensitivity, thereby promoting beneficial downstream effects like muscle protein synthesis and collagen deposition while maintaining overall systemic health.
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