What is the Origin of IGF-1 Axis Support?

The term is derived from the hormone Insulin-like Growth Factor 1 (IGF-1), which shares structural homology with insulin, and axis, referring to the Hypothalamic-Pituitary-Somatic (HPS) pathway that regulates it. Support denotes the clinical objective of modulating this system through lifestyle, nutrition, or specific therapies. The IGF-1 axis is a core component of the somatotropic system, vital for development and adult metabolism.

What is the Mechanism of IGF-1 Axis Support?

The axis is initiated by Growth Hormone (GH) released from the pituitary gland, which travels to the liver and other tissues, stimulating the production and secretion of IGF-1. IGF-1 then acts locally and systemically by binding to the IGF-1 receptor on target cells, activating a downstream signaling cascade, primarily the PI3K/Akt pathway, which promotes protein synthesis and inhibits apoptosis. Nutritional factors, especially adequate protein intake and insulin signaling clarity, are essential for the liver's capacity to convert GH into bioavailable IGF-1, ensuring the axis functions efficiently.

IGF-1 Axis Support ∞ Area

IGF-1 Axis Support

Meaning

IGF-1 Axis Support refers to clinical or nutritional strategies designed to optimize the function and signaling of the Insulin-like Growth Factor 1 (IGF-1) axis, which is a critical mediator of Growth Hormone (GH) action. This axis is central to anabolic processes, promoting cell growth, tissue repair, and the maintenance of lean mass, bone density, and metabolic health. Effective support aims to ensure a stable, healthy level of circulating IGF-1 and optimal sensitivity in its target tissues, which is particularly relevant for mitigating age-related sarcopenia and bone loss.