What is the Origin of IGF-1 and Cancer Risk?

This area of study originated from epidemiological observations linking conditions characterized by high endogenous GH/IGF-1 signaling, such as acromegaly, with increased incidence rates of several cancers, notably colorectal cancer. The mechanism is rooted in IGF-1's primary physiological role as a mediator of growth and cell survival signals initiated by Growth Hormone.

What is the Mechanism of IGF-1 and Cancer Risk?

IGF-1 exerts its proliferative effects by binding to the IGF-1 receptor (IGF-1R), activating downstream pathways like the PI3K/AKT and MAPK cascades, which are central to cell cycle progression and survival signaling. When these pathways are chronically overactivated by high circulating IGF-1, the normal checks and balances that prevent uncontrolled cell division can be bypassed. Maintaining IGF-1 levels within an optimal physiological range is therefore a clinical consideration in preventative endocrinology.

IGF-1 and Cancer Risk

Meaning

The relationship between Insulin-like Growth Factor 1 (IGF-1) and cancer risk posits that elevated, sustained levels of this anabolic peptide hormone may promote cellular proliferation and inhibit apoptosis in various tissues, potentially increasing susceptibility to malignant transformation. Clinically, assessing IGF-1 status is sometimes considered in the context of assessing long-term risks associated with certain endocrine interventions. We analyze this correlation with scientific diligence.

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What Questions Should I Ask My Doctor about a Wellness Protocol They Disagree With?

Engage your physician with structured, evidence-based questions to collaboratively assess if a disputed wellness protocol aligns with your unique biology.

∞ Clinical Dialogue
∞ Growth Hormone
∞ Peptide Therapy

HRTioAugust 10, 2025

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Are There Specific Contraindications for Peptide-Based Metabolic Support in Older Adults?

Peptide support in older adults requires a thorough evaluation, as absolute contraindications like active cancer and relative ones like diabetes must be addressed.

∞ Sermorelin
∞ HGH Release
∞ Contraindications for Peptide Therapy

HRTioAugust 1, 2025