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IGF-1 and Aging

Meaning

IGF-1 and Aging refers to the complex and dynamic relationship between Insulin-like Growth Factor-1 (IGF-1), a peptide hormone structurally similar to insulin, and the biological processes of senescence and longevity. IGF-1, primarily produced in the liver under the stimulation of Growth Hormone, plays a critical anabolic role in childhood and early adulthood, promoting tissue growth, cell proliferation, and repair. The clinical perspective acknowledges that while high levels in early life are beneficial, maintaining excessively high levels in later life may accelerate certain age-related processes, necessitating a nuanced approach to its management.