What is the Origin of IGF-1 Anabolism?

The concept is fundamental to growth and developmental endocrinology, with IGF-1 being discovered as a mediator of GH action, previously termed "sulfation factor." The term "anabolism" is derived from the Greek anabole, meaning "a raising up," describing the constructive phase of metabolism.

What is the Mechanism of IGF-1 Anabolism?

IGF-1 binds to the IGF-1 receptor, a tyrosine kinase receptor, on target cell surfaces, initiating a complex intracellular signaling cascade, notably the PI3K/Akt pathway. This pathway subsequently activates mTOR, which is a master regulator of protein synthesis and cellular growth. Optimizing IGF-1 anabolism is a clinical strategy for improving lean body mass, accelerating injury recovery, and enhancing bone mineral density.

IGF-1 Anabolism ∞ Area

IGF-1 Anabolism

Meaning

IGF-1 Anabolism refers to the constructive metabolic process driven by Insulin-like Growth Factor 1 (IGF-1), a peptide hormone predominantly synthesized in the liver in response to Growth Hormone (GH) stimulation. This specific action promotes the synthesis of complex molecules, such as proteins and nucleic acids, leading to tissue growth, cellular proliferation, and repair, particularly in muscle, bone, and cartilage. It is a key metric for assessing the overall anabolic status of the body.