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IGF-1/Akt/mTOR Pathway

Meaning

The IGF-1/Akt/mTOR Pathway is a major intracellular signaling cascade that regulates fundamental cellular processes, including growth, proliferation, survival, and metabolism, often serving as a central nutrient-sensing mechanism. It is initiated by the binding of Insulin-like Growth Factor 1 (IGF-1) to its receptor, activating the Akt kinase, which subsequently activates the mammalian Target of Rapamycin (mTOR) complex. This pathway is hyperactive in many cancers and is a critical mediator of anabolic effects, making it a key area of study in longevity and muscle health. Modulating this axis is a primary strategy for influencing cellular aging and metabolic state.