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IBIS-II Study

Meaning

The IBIS-II Study, which stands for International Breast Cancer Intervention Study II, is a large, randomized, placebo-controlled clinical trial designed to evaluate the efficacy and safety of specific hormonal therapies for the prevention of breast cancer in high-risk postmenopausal women. This landmark study focused on the use of aromatase inhibitors, particularly anastrozole, as a prophylactic measure against the development of estrogen receptor-positive breast cancer. The findings from IBIS-II have significantly influenced clinical guidelines for breast cancer prevention, demonstrating a tangible benefit of endocrine modulation in a high-risk population.