What is the Origin of Hypothyroidism Skin?

These specific skin conditions originate from the systemic hypometabolic state induced by insufficient circulating thyroid hormones. The term myxedema, which is often used interchangeably with severe hypothyroidism, literally means "mucus swelling," describing the underlying pathological change. The overall slowing of cellular function directly impairs the skin's ability to maintain hydration and normal turnover.

What is the Mechanism of Hypothyroidism Skin?

The underlying mechanism is the accumulation of hydrophilic glycosaminoglycans, particularly hyaluronic acid, within the dermis and subcutaneous tissues due to the decreased degradation rate caused by thyroid hormone deficiency. This mucin deposition draws water, resulting in the non-pitting, doughy edema and characteristic facial puffiness known as myxedema. Furthermore, decreased sebaceous and sweat gland activity contributes to the pronounced xerosis and coarse texture of the skin.

Hypothyroidism Skin ∞ Area

Hypothyroidism Skin

Meaning

Hypothyroidism skin encompasses the array of dermatological signs and symptoms resulting from a deficiency of thyroid hormones, a state commonly referred to as myxedema. The classic presentation involves skin that is notably pale, cool, dry, and coarse, reflecting a generalized slowing of metabolic processes and decreased cellular turnover. Other common findings include xerosis cutis, a scaly dryness, and a characteristic puffiness, especially around the eyes and extremities.