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Hypothyroidism and Testosterone

Meaning

Hypothyroidism and Testosterone describes the clinically significant, interdependent relationship between inadequate thyroid hormone production, which is defined as hypothyroidism, and the circulating levels and biological action of the primary androgen testosterone in both men and women. Thyroid hormones are essential, pervasive regulators of the basal metabolic rate and protein synthesis, fundamentally influencing the production and clearance of the carrier protein Sex Hormone-Binding Globulin (SHBG). Dysregulation in thyroid function can consequently lead to measurable, substantial alterations in both free and total testosterone concentrations, affecting vital functions like muscle mass maintenance, libido, and sustained energy levels. Proper, comprehensive endocrine management therefore requires effectively addressing both axes simultaneously for achieving optimal patient health outcomes.