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Hypothyroidism and HRT

Meaning

Hypothyroidism and HRT describes the clinically significant, intertwined relationship between an underactive thyroid gland (hypothyroidism) and the therapeutic use of Hormone Replacement Therapy (HRT), typically involving estrogen and/or testosterone. This interaction is crucial because exogenous HRT, particularly when administered orally, can significantly alter the metabolism, transport, and functional availability of native and supplemented thyroid hormones. It necessitates careful, proactive monitoring and potential adjustment of thyroid medication dosage to maintain euthyroid status at the cellular level. This represents a common, complex comorbidity in integrated endocrine practice.