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Hypothyroidism

Meaning

Hypothyroidism is an endocrine disorder defined by insufficient production and secretion of thyroid hormones, primarily thyroxine (T4) and triiodothyronine (T3), by the thyroid gland, leading to a generalized slowing of metabolic processes throughout the body. This systemic deficiency results in a broad spectrum of clinical symptoms, including fatigue, weight gain, cold intolerance, and neurocognitive impairment. It is one of the most common endocrine disorders, requiring precise diagnosis and lifelong hormone replacement therapy.