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Hypothalamic Suppression Reversal

Meaning

Hypothalamic Suppression Reversal is a clinical and physiological process aimed at restoring the natural, pulsatile release of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus, which has been inhibited by factors such as chronic stress, specific medications, or exogenous hormone administration. Successful reversal is crucial for reactivating the entire hypothalamic-pituitary-gonadal (HPG) axis, allowing for the endogenous production of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), and ultimately, sex steroids. This intervention is often a necessary step to re-establish the body’s innate hormonal rhythm and self-regulation.