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Hypothalamic Signaling Fidelity

Meaning

The measure of accuracy, precision, and consistency in the pulsatile release of releasing hormones from the hypothalamus, which acts as the master regulator of the endocrine system. High fidelity ensures that downstream glands, like the pituitary and adrenals, receive clear, unambiguous instructions, maintaining the integrity of the entire neuroendocrine axis. Diminished fidelity is often a primary driver of hormonal dysregulation.