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Hypothalamic Satiety Resistance

Meaning

Hypothalamic Satiety Resistance is a state of impaired responsiveness in the appetite-regulating neurons of the hypothalamus to circulating satiety hormones and neural signals that typically indicate fullness and energy sufficiency. Despite adequate levels of hormones like leptin and insulin, the central nervous system fails to register the satiety signal correctly, resulting in a persistent drive to eat and an inability to terminate a meal appropriately. This is a core pathology in many forms of chronic weight gain and metabolic dysfunction.