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Hypothalamic Pulse Generator Recovery

Meaning

Hypothalamic Pulse Generator Recovery is the physiological process by which the neurosecretory neurons in the hypothalamus, responsible for the pulsatile release of Gonadotropin-Releasing Hormone (GnRH), regain their normal rhythmic activity. This recovery is a critical, rate-limiting step following the cessation of suppressive agents, such as high-dose exogenous sex steroids, which inhibit the GnRH pulse generator. The resumption of normal GnRH pulsatility is absolutely essential for re-initiating the entire Hypothalamic-Pituitary-Gonadal (HPG) axis and restoring robust endogenous gonadal function.