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Hypothalamic Pulse Generation

Meaning

Hypothalamic Pulse Generation refers to the rhythmic, pulsatile secretion of Gonadotropin-Releasing Hormone (GnRH) from specialized neurons within the hypothalamus, which is the foundational signal for the entire reproductive endocrine axis. The frequency and amplitude of these GnRH pulses dictate the subsequent release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) from the pituitary gland. This precise, oscillating pattern is absolutely essential for maintaining normal gonadal function and fertility in both males and females. Disruption of this pulse generator, often due to stress or metabolic dysfunction, is a common cause of reproductive hormone deficiency.