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Hypothalamic Pituitary Gonadal Restoration

Meaning

Hypothalamic Pituitary Gonadal (HPG) Restoration is a targeted clinical objective aimed at reviving the endogenous function of the primary reproductive and anabolic hormone axis, particularly after it has been suppressed by factors like exogenous hormone use, chronic stress, or aging. The goal is to stimulate the hypothalamus, pituitary gland, and gonads to resume their natural, synchronized production of sex hormones, thereby re-establishing hormonal self-sufficiency. This approach is central to maintaining long-term reproductive and metabolic health.