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Hypothalamic Insulin Resistance

Meaning

Hypothalamic insulin resistance is a condition characterized by the impaired ability of cells in the hypothalamus, a key brain region, to respond appropriately to the critical metabolic signal of insulin. This specific form of central resistance disrupts the brain’s regulation of systemic energy balance, contributing to peripheral issues like increased appetite, reduced energy expenditure, and overall weight gain. It represents a critical, often overlooked link between central nervous system function and the development of metabolic syndrome.