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Hypopituitarism

Meaning

Hypopituitarism is a clinical syndrome resulting from the partial or complete deficiency of one or more hormones produced by the anterior and/or posterior lobes of the pituitary gland. This condition leads to downstream deficiencies in the target endocrine glands, such as the thyroid, adrenals, and gonads, due to the loss of trophic hormone stimulation. Clinical presentation varies widely depending on which pituitary hormones are affected, often including symptoms like fatigue, sexual dysfunction, cold intolerance, and hypotension. Comprehensive hormonal testing and imaging studies are essential for accurate diagnosis and subsequent hormone replacement therapy.