Hypogonadism Clinical Assessment is the structured, multi-step medical evaluation used to diagnose the presence, etiology, and severity of gonadal dysfunction resulting in insufficient sex hormone production. This comprehensive assessment involves a detailed patient history, a targeted physical examination, and precise laboratory measurement of key hormonal markers. The ultimate goal is to differentiate between primary (gonadal failure) and secondary (hypothalamic-pituitary failure) hypogonadism to inform the most appropriate therapeutic intervention.
Origin
The term combines ‘Hypogonadism,’ rooted in Greek hypo- (under) and gonados (seed/gonads), denoting deficient gonadal function, with ‘Clinical Assessment,’ which refers to the systematic gathering of data for diagnostic purposes in a medical setting.
Mechanism
The assessment mechanism systematically analyzes the Hypothalamic-Pituitary-Gonadal (HPG) axis. Initial screening involves measuring total and free sex hormones, such as testosterone or estradiol, and pituitary gonadotropins, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). Elevated gonadotropins with low sex hormones indicate primary hypogonadism, reflecting gonadal failure and a loss of negative feedback. Conversely, low gonadotropins alongside low sex hormones suggest secondary hypogonadism, pointing to a central regulatory issue in the hypothalamus or pituitary.
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