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Hypogonadism Associated Depression

Meaning

Hypogonadism Associated Depression describes a clinically significant depressive state that is etiologically linked to, and often a direct symptom of, chronic deficiency in gonadal hormones, such as testosterone and estrogen. This condition highlights the profound neuroendocrine influence of sex steroids on mood regulation, cognitive function, and emotional resilience. Effective treatment requires addressing the underlying hormonal deficit, often leading to a resolution of the mood symptoms that are refractory to conventional antidepressant therapy alone.