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Hypogonadal Cognitive Deficits

Meaning

Hypogonadal Cognitive Deficits are the measurable impairments in specific cognitive domains, such as executive function, working memory, and visuospatial abilities, directly attributable to the pathological deficiency of gonadal hormones, primarily testosterone or estrogen. These deficits represent a functional consequence of suboptimal sex steroid signaling within the central nervous system, particularly in brain regions rich in sex hormone receptors like the hippocampus and frontal cortex. Clinically, these impairments contribute significantly to reduced quality of life and functional decline in affected individuals.