Hypocaloric Diet Impact refers to the complex physiological and hormonal consequences resulting from a sustained reduction in energy intake below the body’s total daily energy expenditure. While often employed for weight loss, this impact includes significant alterations in metabolic rate, thyroid function, and the balance of satiety and hunger hormones. The clinical challenge lies in harnessing the beneficial effects of energy restriction while mitigating the potential for negative endocrine adaptations and metabolic slowdown.
Origin
The term combines ‘hypocaloric’ (Greek hypo- meaning under, and Latin calor meaning heat or energy) with ‘diet’ and ‘impact,’ emphasizing the systemic effects of reduced energy availability. It is a concept central to bariatric and nutritional endocrinology, studying the body’s response to energy scarcity.
Mechanism
The primary mechanism involves the body’s perception of energy deficit, which triggers adaptive responses aimed at conserving energy. This includes a reduction in leptin, which signals satiety, and an increase in ghrelin, which stimulates appetite, alongside a compensatory decrease in active thyroid hormone (T3) production. Chronic hypocaloric states can also suppress the HPG axis, leading to reduced sex hormone levels as the body prioritizes survival over reproduction and anabolism.
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