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Hyperinsulinemic-Euglycemic Clamp

Meaning

The Hyperinsulinemic-Euglycemic Clamp is the most rigorous research method utilized in clinical endocrinology to accurately quantify an individual’s in vivo insulin sensitivity. This meticulous procedure involves infusing insulin at a constant, supraphysiological rate to maximize its effect while simultaneously infusing glucose at a variable rate to maintain the plasma glucose concentration within the normal, or euglycemic, range. The precise glucose infusion rate required to prevent hypoglycemia directly measures how effectively insulin is promoting glucose uptake and utilization by peripheral tissues.