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Hydroxyproline

Meaning

Hydroxyproline is a non-essential amino acid, primarily known as a major and unique constituent of the structural protein collagen, where it makes up about 13.5% of the total amino acid content. This amino acid is formed post-translationally by the hydroxylation of proline residues, a process that absolutely requires Vitamin C (ascorbic acid) as a cofactor. Clinically, measuring hydroxyproline levels, particularly in urine, serves as a biomarker for collagen turnover and bone resorption, offering insight into the health of connective tissues and the effectiveness of longevity protocols.