What is the Origin of Humanin Peptide?

Humanin was initially discovered in 2001 through a screen for genes that could protect neuronal cells from the toxicity associated with Alzheimer's disease. Its name reflects its human origin and its potential for promoting human health and longevity. The subsequent discovery of its mitochondrial origin established it as a foundational member of the growing family of mitochondrial-derived peptides.

What is the Mechanism of Humanin Peptide?

The primary mechanism of Humanin involves binding to specific cell surface receptors, including the formyl peptide receptor-like 1 (FPRL1), which triggers intracellular signaling cascades. These pathways ultimately inhibit the intrinsic apoptotic cascade, preventing programmed cell death in vulnerable cells, such as neurons and pancreatic beta cells. Furthermore, Humanin improves mitochondrial efficiency and reduces the production of reactive oxygen species, directly supporting the energy architecture necessary for optimal endocrine function.

Humanin Peptide ∞ Area

Humanin Peptide

Meaning

A small, naturally occurring mitochondrial-derived peptide (MDP) comprised of 24 amino acids, primarily recognized for its potent cytoprotective and anti-apoptotic effects within the body. Humanin plays a crucial role in maintaining cellular viability and mitochondrial function, acting as a key regulator in the cellular response to various forms of metabolic and oxidative stress. Its presence is linked to improved insulin sensitivity and neuroprotection, making it a molecule of significant interest in the context of hormonal longevity and metabolic health. This peptide offers a unique endogenous mechanism for cellular defense against age-related decline.