The complex biological process of renewing, restoring, or growing healthy cells, tissues, and organs to replace those that are damaged or aged, thereby reversing or slowing the effects of senescence. This represents the body’s innate capacity for self-repair and renewal, extending beyond simple wound healing to encompass systemic tissue and cellular turnover. In the context of longevity, Human Regeneration is the ultimate goal of restorative medicine, aiming to restore youthful function across all physiological systems.
Origin
A fundamental concept in developmental biology and regenerative medicine, derived from the Latin re- (again) and generare (to beget). Its clinical application in the longevity space refers to the strategic utilization of modern biological tools to enhance the body’s intrinsic repair mechanisms. The term emphasizes the potential for functional restoration rather than merely slowing decline.
Mechanism
Primarily mediated by the activation and mobilization of endogenous stem cells, the optimization of growth factor signaling pathways (like IGF-1 and Growth Hormone), and the clearance of senescent cells. This process relies on a favorable hormonal environment that promotes anabolic activity and minimizes inflammatory signaling. Targeted interventions often aim to stimulate these pathways to enhance tissue repair, improve organ function, and ultimately contribute to a measurable reversal of biological aging.
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